Host-guest complexation between β-cyclodextrin and phosphonium-based ionic liquid and influence of its inclusion complex on the binding property of paracetamol drug

Abstract

Current research aimed to examine the process of forming inclusion complexes (IC) between β-cyclodextrin and a phosphonium-based ionic liquid i.e., trihexyltetradecylphosphonium bis-(2,4,4-trimethyl pentyl) phosphinate [THTDPP] by UV–Vis spectroscopy and FTIR methods. The co-precipitation technique was utilized to produce the solid IC of [THTDPP] with β-CD, and the Job plot method was employed to understand the 1:1 M ratio stoichiometry and the binding affinity. The Benesi-Hildebrand equation was used to calculate the binding affinity at three unique temperatures, which revealed an increase in the association constant (K) with rising temperature. The Van't Hoff equation was utilized to investigate multiple thermodynamic properties, including the ΔH0 (standard enthalpy changes), ΔS0 (standard entropy changes), and ΔG0 (standard Gibbs free energy changes). The FT-IR analysis indicated notable changes in the IR stretching frequency, providing further evidence of the IC formation. Additionally, the IC was further used to study the aggregation of the Paracetamol drug by UV–Vis spectroscopy and the results indicated a significant improvement in the binding of Paracetamol. Overall, this study sheds important light on the development and properties of IC between β-CD and a phosphonium-based ionic liquid and demonstrates their potential application as an effective drug delivery system.