Abstract
Considering the absence of predictable and effective therapeutic interventions for the treatment of peri-implantitis, scientific evidence concerning the host response profile around dental implants could be important for providing in the future a wider preventive and/or therapeutic window for this peri-implant lesion, indicating biomarkers that provide quantifiable measure of response to peri-implant therapy. Moreover, a better knowledge of pattern of host osteo-immunoinflammatory modulation in the presence of peri-implantitis could either benefit the early diagnostic of the disease or to cooperate to prognostic information related to the status of the peri-implant breakdown. Finally, new evidences concerning the host profile of modulators of inflammation and of osseous tissue metabolism around dental implants could explain the individual susceptibility for developing peri-implant lesions, identifying individuals or sites with increased risk for peri-implantitis. The focus of this chapter was, based on a systematically searched and critically reviewed literature, summarizing the existing knowledge in the scientific research concerning the host osteo-immunoinflammatory response to the microbiological challenge related to periimplantitis.
Highlights
Dental implants present predictable outcomes and characterize a procedure often performed in daily clinical practice for oral rehabilitation, the development and progression of peri-implantitis has expressively impaired implant survival and success.[1,2,3]
Considering the absence of predictable and effective therapeutic interventions for the treatment of peri-implantitis,[15,16] scientific evidence concerning the host response profile around dental implants could be important for providing in the future a wider preventive and/or therapeutic window for this peri-implant lesion, indicating biomarkers that provide quantifiable measure of response to peri-implant therapy
New evidences concerning the host profile of modulators of inflammation and of osseous tissue metabolism around dental implants could explain the individual susceptibility for developing peri-implant lesions, identifying individuals or sites with increased risk for peri-implantitis
Summary
Dental implants present predictable outcomes and characterize a procedure often performed in daily clinical practice for oral rehabilitation, the development and progression of peri-implantitis has expressively impaired implant survival and success.[1,2,3] In this context, Derks and Tomasi[4] reported in a meta-analyses study that weighted implant-based prevalence for peri-implantitis were 22% (95%CI: 14–30), whereas another meta-analysis recognized that weighted implant and patient-based peri-implantitis prevalences achieved 9.25% (95%CI: 7.57–10.93) and 19.83% (95%CI: 15.38–24.27), respectively.[5].
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