Abstract
7 day old mouse egg cylinders transplanted under the renal capsule give rise to both teratomas and teratocarcinomas in mice of C3H/H, CBA and A strains. The proportion of benign to malignant tumors is approximately the same in the three strains. In C57BL mice, only an occasional graft examined histologically 2 months after transplantation of the embryo contains undifferentiated embryonal cells and could thus be considered a teratocarcinoma. None of these “teratocarcinomas” in C57BL mice could be retransplanted and thus unequivocally proven to be malignant. C57BL egg cylinders grafted to C57BL × C3H/H F1 hybrids gave rise to numerous teratocarcinomas. It was possible to obtain teratocarcinomas from C57BL egg cylinders grafted to lethally irradiated isogenic hosts salvaged with the bone marrow cells of C57BL × C3H/HF1 hybrids. These tumors were retransplantable in hybrids but not in inbred C57BL recipients. It was concluded that some host related factors, possibly of an immunologic nature, govern and regulate the outgrowth of tumors from mouse egg cylinders and determine whether the grafted embryo will give rise to benign teratomas or teratocarcinomas.
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