Abstract
AN endogenous C-type virus with an unusual tropism has been isolated from New Zealand Black (NZB) and other mouse strains. Although it has the murine leukaemia virus (MLV) gs-1 antigen and reverse transcriptase, it cannot be propagated in mouse cells. It is only infectious for cells foreign to the host species and has been termed xenotropic1–3. In the course of host range studies, we have discovered that, in contrast to other mammalian C-type viruses, this murine xenotropic virus can cross class barriers and both infect and replicate efficiently in avian cells. In these studies, the NZB pseudotype murine sarcoma virus (MSV) (Table 1) was used as it provides a good marker (focus formation) for NZB virus infection and replication.
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