Abstract
A new 1,3-lower rim-lipoic acid appended calix[4]arene (L) has been synthesized and characterized by different spectral techniques. Lipoic acid functionality helps L to anchor onto a noble metal surface, and in the present case these are the gold nanorods (GNRs). As the conjugate of calix[4]arene acts as a host due to the presence of its arene cavity, pyridinium containing guests have been explored to study their complexation, since the pyridinium containing molecules will accumulate in mitochondria in cells. The host–guest complexation has been explored in solution by 1H NMR, ESI-MS, UV–vis, and fluorescence spectral titration studies. The loading of host and the guest onto the GNR surface has been analyzed by spectroscopy and microscopy and found that their combination results in nanocomplexation. The presence of pyridinium functionality on the guest leads to targeted delivery to mitochondria of GNR nanocomposites as shown by confocal laser scanning microscopy imaging. The nanocomplex has been studied f...
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