Abstract
In vitro and in vivo analyses identified a significant component of heritability in cellular or host susceptibility to HIV-1. The bases for susceptibility can be traced to genetic differences (inter-species) resulting from evolutionary adaptation to exogenous (and endogenous) retroviral infections, and to intra-species and inter-individual (human) differences associated with genetic variation. We have completed large scale evolutionary analysis of genes involved in HIV life cycle and pathogenesis, as well as participating and conducting genome-wide association studies, linkage analysis, and transcriptome analysis. These studies allowed a better understanding of the influence of common human variants in HIV-1 susceptibility and define a number of experimental challenges in the filed: understanding of the role of rare and private mutations in susceptibility, and the development of better tools for the integration of data from large-scale studies.
Highlights
Frontiers of Retrovirology: Complex retroviruses, retroelements and their hosts Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1742-4690-6-S2-info.pdf
In vitro and in vivo analyses identified a significant component of heritability in cellular or host susceptibility to HIV-1
The bases for susceptibility can be traced to genetic differences resulting from evolutionary adaptation to exogenous retroviral infections, and to intra-species and inter-individual differences associated with genetic variation
Summary
In vitro and in vivo analyses identified a significant component of heritability in cellular or host susceptibility to HIV-1. Host genome influences on susceptibility to HIV-1 Amalio Telenti
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