Abstract
Spontaneous clearance of hepatitis B surface antigen (HBsAg) in chronic hepatitis B (CHB) patients usually indicates a remission of hepatitis activity and a favorable outcome. Two single nucleotide polymorphisms (SNP), rs3077 near HLA-DPA1 region and rs9277535 near HLA-DPB1 region, have been shown to be associated with HBV persistence after acute HBV infection. However, little is known about the impact of these 2 SNPs on spontaneous HBsAg clearance in CHB patients. In this case-control study, a total of 100 male HBeAg-negative chronic HBV carriers who cleared HBsAg spontaneously (case group) and 100 age-matched HBeAg-negative male patients with persistent HBsAg positivity (control group) were enrolled. We investigated the relationship between these 2 SNPs and HBsAg clearance. There was a higher frequency of rs9277535 non-GG genotype in the case group (57% vs. 42%). Patients with rs9277535 non-GG genotype had a higher chance to clear HBsAg [Odds ratio (OR): 1.83, 95% confidence interval (CI): 1.04∼3.21, P = 0.034]. Compared to GG haplotype of rs3077 and rs9277535, GA haplotype had a higher chance of achieving spontaneous HBsAg loss (OR: 2.17, 95% CI: 1.14∼4.16, P = 0.030). In conclusion, rs9277535 non-GG genotype is associated with a higher likelihood of spontaneous HBsAg seroclearance in CHB patients.
Highlights
Hepatitis B virus (HBV) infection is a global health problem, resulting in over one million deaths per year [1]
Compare of GG haplotype, GA haplotype was associated with higher chance of Hepatitis B surface antigen (HBsAg) seroclearance (Table 3)
HBsAg loss is an important milestone in the natural history of chronic HBV infection
Summary
Hepatitis B virus (HBV) infection is a global health problem, resulting in over one million deaths per year [1]. Patients with chronic HBV infection are at risk of developing adverse outcomes, including cirrhosis and hepatocellular carcinoma (HCC), with an estimated lifetime risk of 25–40% [1,2,3,4]. Spontaneous HBsAg loss is a rare event, it usually indicates a cure for the disease [5,6]. Previous studies have indicated that HBsAg loss rate is around 0.5 to 1.4% per year in patients with chronic HBV infection [7,8,9,10,11,12,13,14]. Little is known about whether host genetic factor influences spontaneous HBsAg loss in patients with chronic hepatitis B infection
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