Abstract
Host defense peptides are effector molecules of the innate immune system. They show broad antimicrobial action against gram-positive and -negative bacteria, and they likely play a key role in activating and mediating the innate as well as adaptive immune response in infection and inflammation. These features make them of high interest for wound healing research. Non-healing and infected wounds are a major problem in patient care and health care spending. Increasing infection rates, growing bacterial resistance to common antibiotics, and the lack of effective therapeutic options for the treatment of problematic wounds emphasize the need for new approaches in therapy and pathophysiologic understanding. This review focuses on the current knowledge of host defense peptides affecting wound healing and infection. We discuss the current data and highlight the potential future developments in this field of research.
Highlights
Skin and soft tissue infections account for 7% to 10% of hospitalizations and represent one of the most common indications for the use of antimicrobial therapy in the United States [1]
We demonstrated that application of the host defense peptide protegrin-1, a mammalian Host defense peptides (HDPs), led to increased bacterial reduction but decreased survival in a sepsis model in mice
One reason is that the skin innate immune defense function creates a soluble antimicrobial peptide barrier
Summary
Host defense peptides are effector molecules of the innate immune system. They show broad antimicrobial action against gram-positive and -negative bacteria, and they likely play a key role in activating and mediating the innate as well as adaptive immune response in infection and inflammation. These features make them of high interest for wound healing research.
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