Abstract
The role of cell-mediated protection against infection with herpes simplex virus was studied by adoptive immunity. Sensitized spleen cells, obtained from syngeneic mice immunized with herpes simplex virus, protected recipient mice against lethal challenge with herpes simplex virus. Survival was significantly greater in challenged mice that had received washed spleen cells from donor animals immunized with herpes simplex than from control donors. This increase in survival after challenge was associated with a significant decrease in titers of virus in the brains of mice that had received specifically sensitized cells. The decrease in viral titers was evident during the period after challenge when titers of virus peak and most deaths occur. There was no obvious association between increased survival and the levels of antibody and interferon in serum of the challenged animals, but these serum factors still must be considered as possible mediators of the protection conferred by sensitized spleen cells.
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