Abstract
AbstractAdvances in gene editing have made feasible the potential use of gene drive for pest control. Ecological risk assessments will certainly be required before this technology can be released into open fields. In this article, I argue for the importance to include host‐associated differentiation (HAD) as part of ecological risk assessment models due to its potential to modulate gene drive spread and risk. Depending on the context, HAD may hamper or facilitate pest control efforts using gene drives. Overlooking HAD may impair pest suppression goals and inflate estimations of effective population sizes, whereas its inclusion within gene drive deployment strategies, as a form of ecological containment, may facilitate gene drive implementation under specific scenarios. Because HAD varies geographically and among closely related species, it will need to be assessed on a case‐by‐case basis. Failure to incorporate HAD within ecological risk assessment models may undermine pest control goals and diminish the accuracy of estimated ecological risks associated with gene drive releases.
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