Abstract
Introduction: Meningococcal disease occurs due to infection by the bacterium Neisseria meningitidis, which is classified according to serogroups. Objective: To survey the profile of hospitalizations and prevalent serogroups of meningococcal infection in the southern region of Brazil. Design and Setting: Is an observational, cross-sectional study using public use data. Methods: The data were taken from the DATASUS, in the year 2020, in states of Paraná (PR), Santa Catarina (SC), and Rio Grande do Sul (RS). Results: In 2020 there were 139 hospitalizations, 76 in RS, 38 in PR and 25 in SC. In RS the most affected age group was 70- 79 years, in PR 60-69 and in SC 30-39. In all states, the male sex had the highest number of hospitalizations. The prevalence of serogroups in RS were B and Y, in PR B and C 1 and in SC, B. The category of ‘’Ignored/Blank’’ stands out in all regions. Conclusion: The highest number of hospitalizations was in RS and in male patients over 30 years old. The large number of serotypes filled in as ignored/blank denotes inadequate data updating, reinforcing the need for regular training for health professionals, so that the filled out data will allow a better configuration of the disease and implementation of public health measures.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
Objectives: The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
The analyses showed significantly higher frequency of the genotype VV in those who had depression, compared with the allele A
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Neuroinfections are pathologies that affect the CNS, for example, we have Murcomycosis, a progressive infection caused by opportunistic fungi of the order Mucorales, with high frequency in Immunodepressed patients, Diabetes Mellitus (DM) is the main underlying pathology associated with the development of Rhinocerebral Murcomycosis, which represents 50% of the cases, with a mortality rate of 70% (Sidrim, 2012, p.168). The COVID-19 pandemic has been alarming the world since its first outbreak in December 2019 In this scenario, the presence of aggravating factors such as the elevation of the D-dimer and the reduction of the angiotensin-converting enzyme 2 (ACE2) during the clinical course of the disease, collaborated in the appearance of thromboembolic events derived from inflammatory processes and extensive intravascular coagulation, contributing to the emergence of diseases such as Hemorrhagic Stroke (ICH), leading the patient to have a worse clinical prognosis and a consecutive worsening of their health. Despite being classically associated with this etiology, the finding may be present in other diseases, especially infiltrative ones
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