Abstract
BackgroudTo assess the value of D-dimer and its combination with The Global Registry of Acute Coronary Events (GRACE) score in predicting in-hospital mortality in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).MethodsIn 5923 ACS patients undergoing PCI, the role of D-dimer and the added value of D-dimer to GRACE score for predicting in-hospital mortality were tested.ResultsAfter multivariable adjustment, D-dimer could significantly predict in-hospital mortality. Also, it could significantly improve the prognostic performance of GRACE score (C-statistic: z = 2.269, p = 0.023; IDI: 0.016, p = 0.032; NRI: 0.291, p = 0.035).ConclusionIn patients with ACS undergoing PCI, D-dimer was an independent predictor of in-hospital death. It could also improve the prognostic performance of GRACE score.
Highlights
Acute coronary syndrome (ACS) patients still have a poor prognosis, even receiving timely percutaneous coronary intervention (PCI) and/or adequate antiplatelet drugs [1,2,3,4]
It had a tendency towards increasing age, heart rate, Global Registry of Acute Coronary Events (GRACE) score, fibrinogen, Troponin-I, creatinine, leukocyte count and Brain natriuretic peptide (BNP) on admission
This study focused on the association between D-dimer and in-hospital mortality in ACS patients undergoing PCI
Summary
Acute coronary syndrome (ACS) patients still have a poor prognosis, even receiving timely percutaneous coronary intervention (PCI) and/or adequate antiplatelet drugs [1,2,3,4]. D-dimer is a kind of degradation product of fibrin [5]. It is a biomarker of coagulation state and the form of thrombosis [5]. Many studies confirmed the association between higher D-dimer and the increased long-term mortality in patients with stable coronary artery disease [10, 11], ACS [12] and ST-segment elevation myocardial infarction (STEMI) [13, 14].
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