Horse Placental Extract Enhances Neurogenesis in the Presence of Amyloid β.

Andreia De Toledo,Kaori Nomoto,Eiichi Hirano,Chihiro Tohda

doi:10.3390/nu13051672

Andreia De Toledo, Kaori Nomoto + Show 2 more

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https://doi.org/10.3390/nu13051672

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Journal: Nutrients	Publication Date: May 14, 2021
Citations: 5	License type: CC BY 4.0

Affiliation: Japan Bio Products (Japan), University of Toyama

Abstract

Human placental extract and animal-derived placental extracts from pigs and horses host a wide range of biological activities. Several placental products are used as medicines, cosmetics, and healthcare substances worldwide. However, the use of placental extracts for neuronal functioning is currently not established because the number of relevant studies is limited. A few previous reports suggested the neuroprotective effect and dendrite genesis effect of placental extract. However, no studies have reported on neurogenesis in placental extracts. Therefore, we aimed to investigate the effects of horse placental extract on neurogenesis, and we examined the protective effect of the extract on the onset of memory disorder. A horse placental extract, JBP-F-02, was used in this study. JBP-F-02 treatment dose-dependently increased the number of neural stem cells and dendrite length under Aβ treatment in primary cultured cortical cells. The oral administration of JBP-F-02 to a 5XFAD mouse model of Alzheimer’s disease at a young age significantly prevented the onset of memory dysfunction. This study suggests that the extract has the potential to prevent dementia.

Highlights

Section of Neuromedical Science, Division of Bioscience, Institute of Natural Medicine, University of Toyama, Abstract: Human placental extract and animal-derived placental extracts from pigs and horses host a wide range of biological activities
An increase in dendrite length was achieved by human placental extract in amyloid β (Aβ)-treated primary cultured cortical neurons [3]
Previous studies of porcine placental extract showed that doses of 242 and 2424 mg/kg/day extract were administered via gavage to 5XFAD mice [3]

Summary

Introduction

The oral administration of JBP-F-02 to a 5XFAD mouse model of Alzheimer’s disease at a young age significantly prevented the onset of memory dysfunction. Our previous study indicated that the administration of porcine placental extract for 4 weeks facilitated memory functioning in aged (76 weeks old) mice [2]. We previously reported that the administration of either human placental extract or porcine placental extract for 15 days significantly improved memory disorder in a 5XFAD mouse model of post-onset. An increase in dendrite length was achieved by human placental extract in amyloid β (Aβ)-treated primary cultured cortical neurons [3]. These data suggest that dendrite growth is an important factor in placental extract-induced memory recovery.

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