Abstract
Conventional treatment for premature ovarian failure consists of oral contraceptives (OCs) or menopausal hormone therapy. In an open-label, randomized, crossover trial, investigators in Scotland compared the effects of an OC (30 µg of ethinyl estradiol and 1.5 mg of norethindrone daily for 21 days, followed by 7 hormone-free days) with those of transdermal estrogen (0.1-mg estradiol patch, week 1; 0.15-mg patch, weeks 2 and 3; no estrogen, week 4) plus cyclical vaginal …
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