Abstract
BackgroundHormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of randomised trials which suggested that HRT reduced non-vertebral fractures by 30%. In this analysis we extend that analysis to vertebral fractures.MethodsWe searched the main electronic databases until the end of August 2001. We sought all randomised controlled trials (RCTs) of HRT where women had been randomised to at least 12 months of HRT or to no HRT.ResultsWe found 13 RCTs. Overall there was a 33% reduction in vertebral factures (95% confidence interval (CI) 45% to 98%).ConclusionsThis review and meta-analysis showed a significant reduction in vertebral fractures associated with HRT use.
Highlights
Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women
We have recently reported in a systematic review of 22 randomised-controlled trials that hormone replacement therapy (HRT) reduces non-vertebral fractures by about 30% [3]
To see if there were a similar effect on vertebral fractures we have extended our review to include such fractures
Summary
Hormone replacement therapy (HRT) is often seen as the treatment of choice for preventing fractures in women. We undertook a recent meta-analysis of randomised trials which suggested that HRT reduced non-vertebral fractures by 30%. In this analysis we extend that analysis to vertebral fractures. Hormone replacement therapy (HRT) is often considered to reduce vertebral fractures by about 60% [1]. This view is based upon the results of one trial, which counted the number of fractures rather than the number of women with fractures. We have recently reported in a systematic review of 22 randomised-controlled trials that hormone replacement therapy (HRT) reduces non-vertebral fractures by about 30% [3]. To see if there were a similar effect on vertebral fractures we have extended our review to include such fractures
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