Abstract
Objectives: Uterine papillary serous carcinoma (UPSC) is an aggressive endometrial cancer (EC) that has classically been characterized by both p53 mutations and lack of estrogen receptor (ER). However, ER expression is increasingly being recognized in UPSC. The clinical interpretation of ER in EC is drawn from the breast literature, with “positive” being defined as ≥1% of tumor nuclei staining, and there is inconsistency between studies regarding its relationship to long-term oncology outcomes. The objective of this work was to assess recurrence-free survival and EC-related death in UPSC according to ER and progesterone receptor (PR) expression, comparing definitional cutoffs of 1% and 10% for positivity.
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