Hormone Metabolism Genes and Mammographic Density in Singapore Chinese Women

Abstract

Female steroid hormone levels and exogenous hormone use influence breast cancer risk. We investigated the association between genetic variation in the hormone metabolism and signaling pathway and mammographic density, a strong predictor of breast cancer risk. We genotyped 161 SNPs in 15 hormone metabolism pathway gene regions and evaluated mammographic density in 2,038 Singapore Chinese women. Linear regression analysis was used to investigate single-nucleotide polymorphism (SNP) and mammographic density association. An overall pathway summary was obtained using the adaptive ranked truncated product test. We did not find any of the individually tested SNPs to be associated with mammographic density after a multiple testing correction. There was no evidence of an overall effect on mammographic density of genetic variation in the hormone metabolism pathway. In this cross-sectional study, genetic variation in hormone metabolism pathway was not associated with mammographic density in Singapore Chinese women. Consistent with existing data from Caucasian populations, polymorphisms in hormone pathway genes are not likely to be strong predictors of mammographic density in Asian women.