Abstract
The technique of organ culture was used to investigate the regulation of the increase of hydroxyindole.O.methyltransferase activity of the pineal gland during embryonic development. Glands of 15- and 17-day chick embryos developed small increases of enzyme activity when incubated in organ culture with a standard tissue culture medium. The increase of enzyme activity was markedly stimulated by a combination of hydrocortisone, somatotropin and thyroxine, and simulated the pre-hatch increase found in ovo . All three hormones appeared to be required for consistent development of maximal increases in enzyme activity but none was essential for some increase in activity.
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