Hormone exposure and functional lateralisation: Examining the contributions of prenatal and later life hormonal exposure

Abstract

An increasing amount of research has shown a relationship between hormonal exposure and functional lateralisation. In this study different sources of hormonal exposure were examined: prenatal exposure, estimated using the 2D:4D ratio, and later life exposure through examining the effects of hormone replacement therapy. In addition to considering multiple sources of hormonal exposure, three tests of functional lateralisation were used: two versions of the chimeric faces test, one using positive emotion and the other using negative emotion, and the landmark task. The same effects were found across all three measures of lateralisation. Lower 2D:4D ratios, which indicate high levels of prenatal testosterone exposure, were associated with stronger right hemisphere dominance. Later life hormonal exposure was not found to be associated with any of the lateralisation measures. This finding suggests a relationship between prenatal hormonal exposure and brain organisation.