Abstract
The first successful systemic therapy for breast Cancer was described by Beatson exactly one century ago []. By translating his observations of the ovarian control of mammary epithelial proliferation in lactating sheep to the epithelial proliferation seen in human cancer, he reasoned that oophorectomy might play a role in controlling the growth of breast cancer. The first oophorectomy in an attempt to suppress breast cancer was carried out on June 15, 1895, and the patient had and excellent response. Subsequently, oophorectomy has become a standard therapy for advanced breast cancer in premenopausal women. Over the intervening years, various hormonal manipulations have been developed to treat earlier stages of breast carcinoma. Favorable results from these interventions, in combination with a growing understanding of the biology of breast carcinoma, have fostered the hope that hormonal manipulations may prevent breast cancers.
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