Abstract
The role of reproductive factors in the aetiology of ovarian cancer had been evaluated in hospital-based case-control study conducted in Albania, providing a total dataset of 283 cases and 1019 controls. Logistic regression models were used to obtain relative risk (OR) estimates. The present results showed that parity had protective effects which increased until the forth birth and the trend in risk was significant (p < 0.01). In each stratum and overall, nulliparous women appeared to be at highly increased risk compared to those who had different number of births (OR=12.5, 95%, CI: 2.4-63.8). Evaluation of early age at menarche and late age at menopause, showed statistically significant increased risk. Furthermore, increased risk was observed between pre-menopausal women and never-married nulliparity women, respectively (OR=1.44 95%, CI: 0.88-2.36; OR=8.98, 95%, CI: 1.44 - 56.14), but ovarian cancer risk was reduced for hysterectomized women. These findings suggest that Albanian women have risk factors similar to women in western countries.
Highlights
MATERIALS AND METHODSPatients We began collecting data for ovarian cancer cases from January through December , identifying
Submitted: 28 October 2012 / Accepted: 9 February 2013
Increased risk was observed between pre-menopausal women and never-married nulliparity women, respectively (OR= . , confidence intervals (CIs): . - . ; obtain relative risk (OR)= ., CI: . - . ), but ovarian cancer risk was reduced for hysterectomized women
Summary
Patients We began collecting data for ovarian cancer cases from January through December , identifying. Hormone-related risk factors of ovarian cancer available for analysis included the following: age at menarche, age at menopause, number of children born, age at first full-term pregnancy, history of abortion and hysterectomy. Controls were obtained from other hospitals through random selection for non-neoplastic, non-gynecological conditions These women were outpatients receiving primary care, in the same source area as the cases. Controls answered a standardized questionnaire on age ( -year categories), marital status, age at menarche (= years), number of abortions, number of children ( , - , - , - , > or full-term pregnancies), age at menopause (premenopausal, < , or ≥ years), hysterechtomy (no or yes), and family reproductive history of ovarian cancer. All statistical tests were two-sided, and p values of . or less were considered significant
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