Abstract
We have studied the effects of hypophysectomy on hormonally induced “relaxation” of the pubic symphysis of mice. Hypophysectomy prevented interpubic ligament formation due to injection of estradiol cyclopentylpropionate (ECP). Combinations of ECP and relaxin were likewise less effective in hypophysectomized than in unoperated mice. Administration of thyroid did not improve the effectiveness of ECP, but enhanced the activity of a combination of ECP and relaxin, in hypophysectomized mice. STH preparations restored pubic ligament response both to ECP and to the combination of ECP and relaxin. Evidence is presented which suggests, but does not prove, that the action of STH extracts on the symphysis pubis may be due to STH activity proper, and not to contaminants.
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