Hormonal Replacement Therapy in Surgically Induced Menopause: A Prospective Cross Section Study from a Tertiary Care Institution from A Sub-himalayan State

Jatinder Kumar Mokta,Arjun Tandon,Renuka Pathania,Akshit Negi,Monica Raj,Arnav Mokta,Aniketa Sharma,- Ramesh Ramesh,Kiran Kumar Mokta

doi:10.7575/aiac.abcmed.v.9n.3p.10

Jatinder Kumar Mokta, Arjun Tandon + Show 7 more

Open Access

https://doi.org/10.7575/aiac.abcmed.v.9n.3p.10

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Abstract

Background: Early surgical menopause increases risk of cardiovascular disease, osteoporosis, fracture, cognitive impairment and sexual dysfunction than women with late menopause. Estrogen therapy (ET) remains the most effective therapy for vasomotor symptoms related to surgically induced menopause. Meterials and Methods: It was a prospective cross-section study. Result: Amongst 255 symptomatic women, 163 (63.92%) women had severe vasomotor symptoms and 54 (33.12% of 163 women) of them had very incapacitating symptoms with marked reduction in their quality of life. 59 (23.13%) women had moderate symptoms with mild disturbances in their sleep while 33 (12.94%) women had only mild symptoms. Conclusion: It is agreed that women who undergo bilateral oophorectomy before the onset of natural menopause should be considered for estrogen therapy for the management of vasomotor symptoms until the average age of natural menopause.

Highlights

Menopause represents permanent cessation of menstrual periods
It is agreed that women who undergo bilateral oophorectomy before the onset of natural menopause should be considered for estrogen therapy for the management of vasomotor symptoms until the average age of natural menopause
Women were not counselled about vasomotor symptoms and genitourinary syndrome after bilateral oophorectomy at the time of discharge and neither were they educated about increased risk for coronary artery disease, osteoporosis and cognitive decline

Summary

Introduction

Menopause represents permanent cessation of menstrual periods. It can occur spontaneously (natural menopause) or can be induced surgically by hysterectomy with bilateral salpingo-oophorectomy. The ovarian function and menstrual activity decline gradually in a synchronized fashion over a period of 12 months or more in women who experience natural menopause; women who underwent surgical menopause had abrupt cessation of both ovarian function and menstrual activity. The abrupt cessation of ovarian function in premenopausal women in surgically induced (bilateral oophorectomy) menopause is associated with more severe vasomotor symptoms (hot flashes and night sweats) and adversely affects the quality of life and relationship. Conclusion: It is agreed that women who undergo bilateral oophorectomy before the onset of natural menopause should be considered for estrogen therapy for the management of vasomotor symptoms until the average age of natural menopause

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Discussion

Conclusion