Abstract
The influences of oestrogen and progesterone administration on the morphology and antigenicity of the submandibular glands of rats were evaluated. The percent distribution of tubules was depressed by ovariectomy of mature female rats but was restored by administration of oestrogen and/or progesterone. The percent distribution of acini of submandibular glands of young rats was slightly increased by oestrogen. The antigenicity of the submandibular glands was determined by their ability to induce experimental autoallergic lesions in the submandibular glands of Lewis rats when administered with adjuvants. Because the antigenicity of the submandibular glands in mature and young female rats was primarily dependent upon progesterone but not upon oestrogen, it appears that submandibular gland antigenicity, in terms of lesion induction, is not intimately related to submandibular gland morphology. Progesterone has a maximal effect on the gland antigenicity while both oestrogen and progesterone have an equal influence on submandibular gland morphology.
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