Abstract
The hormonal dependence of fluid reabsorption has been studied in isolated rat cauda epididymidis. In a group of experiments, rats were castrated by removal of the testes but leaving the epididymis with the blood supply intact. The rate of fluid reabsorption measured 3 weeks after castration fell from the control value of 2.10 ± 0.10 μl/cm2/30 min to 0.82 ± 0.12 μl/cm2/min (P < 0.001). When testosterone propionate (2 mg/kg/day) was injected into castrated rats for 7 days, the rate of fluid reabsorption was restored. This suggests that fluid reabsorption in rat cauda epididymidis is dependent on the presence of circulating androgen. Adrenalectomy in rats did not affect the rate of fluid reabsorption or did treatment of the epididymal ducts with aldosterone (10−6M) in vitro. Both LH (5 μg/ml) and FSH (5 μg/ml) produced a small but significant increase in the rate of fluid reabsorption. Of the other hormones studied, vasopressin (10 mU/ml) increased the reabsorption rate by 15%. Acetylcholine (10−5M) produce...
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