Abstract
Summary The oral and intravenous LD50's were determined for monocrotaline. The LD50 was essentially the same for males and females and for oral and intravenous administration for a 90-day observation period. There was a marked sex difference with respect to the median survival time, females living significantly longer than males. Castration of either male or female rats had no significant effect on the median survival time. Pretreatment of males with estradiol cyclopentylpropionate caused the median survival time to correspond to that of females. Pretreatment of females with testosterone propionate caused the median survival time to approximate that of male animals. Pretreatment of female rats with methandrostenolone (Dianabol), an anabolic agent, caused the median survival time to correspond to that of males. No sex difference was observed when monocrotaline was administered to immature rats at 4 weeks of age, implicating the female sex hormones as the dominant factor in the sex variation in adult animals. The observed sex difference in Osborne-Mendel rats carries over to other strains of rats but was not observed when monocrotaline was administered to mice or guinea pigs.
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