Hormonal interaction in the regulation of granulation tissue formation.

Abstract

In our previous investigations (Taubenhaus and Amromin 1949–1950) it was shown, that estradiol, testosterone, ACTH and cortisone exhibit a suppressing effect upon the granulation tissue which forms around turpentine abscesses in rats. Desoxycorticosterone (DOCA) and antericr pituitary growth hormone on the other hand promote formation of such tissue. Thyroxin stimulates granulation tissue only in thyroidectomized or hypophysectomized animals. The present study is an attempt to demonstrate synergistic or antagonistic effects, following the treatment of the same animal with two different hormonal substances. Methylandrostenediol was included in these studies, because this material was shown to have some of the metabolic properties of testosterone, but to produce minor changes in secondary sex characters (Henderson and Weissberg, 1951). Cortisone was chosen as the basic substance, the antagonistic and synergistic actions of the other hormones being tested in relation to its powerful inhibitory effect.