Abstract
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders of women at reproductive age and the major cause of anovulatory infertility. The aim of this study is to determine hormonal imbalance in women with PCOS in teaching hospitals in Ekiti State, Nigeria. Samples of 110 females (50 freshly diagnosed PCOS subjects and 60 healthy subjects) between the ages of 25 - 45 years old were collected from Ekiti State University Teaching Hospital, Ado Ekiti and Federal Teaching Hospital, Ido Ekiti, Ekiti State, Nigeria. Serum Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH), Total Testosterone, Prolactin, Progesterone, Estradiol and Insulin were evaluated in subjects’ blood sample using Enzyme-Linked Immunosorbent assay (ELISA). Results obtained were subjected to statistical analysis (p > 0.05) when compared with the healthy control group. Hormonal values obtained in this study indicates hormonal imbalance in PCOS. Further investigation into novel helpful markers is required as it might help in achieving the therapeutical target in PCOS management research.
Highlights
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders of women at reproductive age and the major cause of anovulatory infertility [1] [2]
Samples of 110 females (50 freshly diagnosed PCOS subjects and 60 healthy subjects) between the ages of 25 - 45 years old were collected from Ekiti State University Teaching Hospital, Ado Ekiti and Federal Teaching Hospital, Ido Ekiti, Ekiti State, Nigeria
In the PCOS subjects when compared with the control subjects
Summary
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders of women at reproductive age and the major cause of anovulatory infertility [1] [2]. PCOS affects about 4% - 12% of women, predominantly women of reproductive age with unclear etiologies [3]. This syndrome has the heterogenous collection of the signs and symptoms that gathered together to form a spectrum of disorder with the mild representation in some, whilst in others a severe disturbance of reproductive, endocrine and metabolic function [3]. Insulin resistance has being reported a key pathophysiology of PCOS [9]
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