Abstract
Normal albino rats exposed to 1500 r of whole-body Co60 gamma radiation were found to have a significant increase in urinary creatine excretion for the first 3 postirradiation days. Adrenalectomized rats, irradiated at 8 days postoperatively, did not show a creatinuria significantly greater than nonirradiated controls. Thyroparathyroidectomized rats, irradiated at 8 days postoperatively, did not have a significant increase in urinary creatine excretion over that of nonirradiated fasted controls. There were no significant increases in polyuria or polydipsia on the 1st postirradiation day in either the adrenalectomized or thyroparathyroidectomized rats. The intramuscular injection of 500 mu of the antidiuretic hormone vasopressin (Pitressin tannate) in oil inhibited postirradiation polydipsia and polyuria in normal rats but significantly increased the urinary excretion of creatine over that of irradiated noninjected controls.
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