Abstract
The effects of ACTH and G.H. on glycine-U-C 14 and lysine-U-C 14 incorporation into rat adrenal protein in vitro have been investigated. Increased incorporation was obtained with either ACTH or G.H. but, in combination, there was an inhibitory effect. A dose-response relationship was obtained with both hormones. The effect of either ACTH or G.H. was present in both Krebs-Ringer bicarbonate and phosphate buffer but was inhibited by the presence of 10 m M glucose in the incubation medium. Significant incorporation of amino acids into protein took place after 15 min. of incubation and increased with time up to 1 hr. There was no decrease in incorporation when the glycine concentration was increased 20-fold.
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