Abstract
The pharmacologic effects of the adrenal cortical hormone, cortisol, and its synthetic congeners on normal tissues can be viewed as a reallocation of the resources of the organism. Under the influence of these compounds, peripheral organs, including the skin, are systematically robbed of their constituents in an exaggerated reenactment of primitive defense reactions. Teleologically, it appears that the glucocorticoids remove materials from some tissues in an effort to preserve normal functioning in other organs. One finds wastage of lymphatic, osseous, muscular, and dermal tissues; at the same time, the liver, receiving the breakdown products of these organ systems, has an enhanced synthesis of ribonucleic acid (RNA), produces increased amounts of glucose and glycogen, and synthesizes selected enzymes of amino acid and carbohydrate metabolism at increased rates.
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