Hormonal disorders in acute glomerulonephritis in patients of young age

Abstract

Goal: To study and asses the role of hormone imbalance (blood TSH, T3, T4, their antibodies, prolactin, cortisol and testosterone levels) in the development of acute glomerulonephritis in adaptational problems in the contingent of the Armed Forces of the Republic of Armenia. Material and methods. To achieve the goal of the study 150 military servicemen (conscripts), aged 18-22, who were hospitalized for acute glomerulonephritis during the first 6 months of their service, were examined. The control group consisted of 50 practically healthy servicemen. Apart from common clinical and laboratory and instrumental examinations, blood serum levels of cortisol, testosterone, prolactin, TTG, T3, T4, antiTG and antiTPO were determined by immuno-fermentative analysis taking into account their circadian rhythms in young organism. Results. In patients with acute glomerulonephritis with acute nephritic syndrome and isolated urinary syndrome extensive increase in prolactin levels, cortisol levels and in T4 levels was observed in relation to comparison group. In both study groups, other data were within normal range in relation to comparison group. Conclusion. In acute glomerulonephritis the adaptation process of young organism is accompanied by certain phase shifts in endocrine system, which manifests with hyperprolactinemia, increased cortisol and thyroxine levels. Prolonged duration of these increased levels can lead to overexertion of the protective adaptation reactions of body and ultimately to their exhaustion. Taking into consideration the abovementioned changes, we consider it necessary to carry out hormonal tests when examining patients with acute glomerulonephritis, and in case of detecting deviations - take the patients under endocrinologist’s follow-up.