Abstract
Summary. Increased plasma erythropoietic activity was observed during pregnancy in the mouse, first appearing on the 5th day. Reticulocytosis, increase of red‐cell volume, decrease of plasma iron and increase of the total iron binding capacity appeared on the 10th day. The major increase of red‐cell volume and plasma volume occurred during late pregnancy as the reticulocytes and plasma iron progressively decreased. Suppression of endogenous erythropoietin production in pregnant mice by hyperoxia did not completely abolish either plasma erythropoietic activity or the rise of the red‐cell volume observed in unexposed pregnant mice. Placental lactogen was found to have some erythropoietic activity and increased the plasma volume. Ovarian hormones were erythropoietically ineffective and, in fact, oestrogen appeared to inhibit the activity of placental lactogen.
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