Abstract
The aim of the present study to identify the influence of aflatoxins (9mg/kgb.w) in the sum of hormone levels Total thyroxin, Testosterone and Luteinizing hormonein BALB/c mice and the protective effects of pretreatment of the three concentrations of Panax ginseng(150mg / kg b.w) , (100mg / kg b.w) and (50mg / kg b.w) At the end of administrated interval, the laboratory animals had weighted and killed to obtain blood samples in order toidentify the changes in the level of thyroid hormones T4 as well as testosterone and Luteinizing hormonethe results showed as follows: 1- Reducing in the level of hormone T4 , testosterone and Luteinizing hormone LH in the blood serum of the aflatoxins AFs (9mg/kgb.w) animals group when compared with control. 2- Increasing in the level of T4, testosterone and Luteinizing hormone LH of each Animals administrated pretreatment with Panax ginseng at the tree concentrations. 3- The best protective effects against Aflatoxins in current study done by the concentrations (150mg / kg b.w) of Panax ginseng extract.
Highlights
Aflatoxins have been described to interfere with the functioning of the number of endocrine glands by disrupting the enzymes and their substrates that are responsible for the synthesis of the various hormones
Aspergillus flavusisolates were obtained from the Biotechnology Department, Science College/Baghdad University, they were cultured on rice medium, Aflatoxins production in rice medium, extraction and analysis using High Performance Liquid Chromatography (HPLC) (Omar, 2012)
The measurably huge reductions were seen in the levels of blood TT4, Teststeron and luteinizing hormone (LH) in all trial bunches contrasted with the control bunch
Summary
Aflatoxins have been described to interfere with the functioning of the number of endocrine glands by disrupting the enzymes and their substrates that are responsible for the synthesis of the various hormones. Aflatoxins and their metabolites as well as the generated ROS have been reported to cause various cancers in diverse endocrine glands like pituitary gland, granulosa cell tumors of the ovary and adenomas and adenocarcinomas of the adrenal gland, kidneys, thyroid gland, ovaries, testes, thyroid gland, parathyroid glands and endocrine pancreas (Gupta, 2011, Agag, 2004). Previous studies have shown that ginseng control hormonal secretion (Kim, 1999)
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