Hormonal and Biochemical Factors in Serum of Pre- and Post-menopausal Iraqi Women with Breast Cancer.

Abstract

Objective: Breast cancer is the most common cancer in women next to cervical cancer. Multiple factors are associated with an increased risk of developing breast carcinoma. The aim of this study was to evaluate the hormonal and biochemical parameters of pre- and postmenopausal women affected with breast cancer. Methods: This study included 30 patients with per-treatment BC stage III consisted of (15 premenopausal and 15 postmenopausal women), also 40 women (20 premenopausal and 20 postmenopausal) were age matched apparently healthy control subjects on routine checkup. Premenopausal women (patients and control) were age ranged (40±8) years and postmenopausal women with mean age ranged (60±10) years. Patients and control have biochemical assay of lactate dehydrogenase, alkaline phosphatase, γ-glutamyl transferase , superoxide dismutase , prolactin , estrogen and lipid profile (total cholecterol, triacylglycerol, high density lipoprotein-cholecterol, very low density lipoprotein and low density lipoprotein- cholesterol). Samples were collected from January 2017 to June 2017 of Tikrit Teaching Hospital. Results and Conclusions:- Levels of lactate dehydrogenase, alkaline phosphatase, γ-glutamyl transferase , prolactin , estrogen and lipid profile (except high density lipoprotein- cholecterol ) were increased in serum of pre- and postmenopausal patients when compared with control but superoxide dismutase and high density lipoprotein-cholesterol , were decreased in serum of pre- and pos-tmenopausal patients when compared with control . These data showed that lactate dehydrogenase, alkaline phosphatase, γ-glutamyl transferase, superoxide dismutase, estrogen and triacylglycerol will be reliable markers in breast cancer and can be used as differential diagnostic in both of pre- and postmenopausal women.