Abstract
Two new aromatic esters Horizontoate A (=4-(2-methylhexyl)oxy)carbonyl)benzoic acid; 1) and B (=2-methylpentyl 4-methoxybenzoate; 2), along with one new sphingolipid C (=(Z)-N-((2S,3S,4R)-1,3,4-trihydroxyhexadecan-2-yl)tridec-10-enamide; 3), were isolated from Cotoneaster horizontalis Decne. Their structures were elucidated by chemical and spectroscopic techniques. Compounds 1 and 2 showed significant inhibitory effects on acetylcholinesterase (AChE) and butylcholinesterase (BChE) in a dose-dependent manner, while compound 3 was found inactive. The IC50 values of compounds 1 and 2 were 1.54 and 3.41μM against AChE and 5.97 and 6.84μM against BChE.
Published Version
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