Abstract
Aim:To study the conserved basis for gene expression in comparative cell types at opposite ends of the cell pressuromodulation spectrum, the lymphatic endothelial cell and the blood microvascular capillary endothelial cell.Methods:The mechanism for gene expression is studied in terms of the 5′ -> 3′ direction paired point tropy quotients (prpTQs) and the final 5′ -> 3′ direction episodic sub-episode block sums split-integrated weighted average-averaged gene overexpression tropy quotient (esebssiwaagoTQ).Results:The final 5′ -> 3′ esebssiwaagoTQ classifies an lymphatic endothelial cell overexpressed gene as a supra-pressuromodulated gene (esebssiwaagoTQ ≥ 0.25 < 0.75) every time and classifies a blood microvascular capillary endothelial cell overexpressed gene every time as an infra-pressuromodulated gene (esebssiwaagoTQ < 0.25) (100% sensitivity; 100% specificity).Conclusion:Horizontal alignment of 5′ -> 3′ intergene distance segment tropy wrt the gene is the basis for DNA transcription in the pressuromodulated state.
Highlights
It can be postulated with a reason degree of certainty that the conserved basis for DNA transcription and replicative gene overexpression progression to mitogenic multi-nucleation is associated with decreased cell membrane compliance primarily related to increased endocytic cell membrane pressuromodulation, which results in mitogenic multi-nucleation, for example:
Horizontal alignment of 5′ -> 3′ direction intergene distance segment tropy with respect to the gene is the conserved basis for DNA transcription for genes in the pressuromodulated state
Future perspective Based on the findings of this study, the final 5′ -> 3′ esebssiwaagoTQ accurately classifies a gene as either a supra-pressuromodulated gene (Supra: esebssiwaagoTQ ≥ 0.25 < 0.75) every time or an infra-pressuromodulated gene (Infra: esebssiwaagoTQ < 0.25) every time (100% sensitivity; 100% specificity), and is
Summary
Freelance Investigator in Translational Science & Medicine (unaffiliated), 833 Carroll Road, Charleston, WV 25314, USA hemantsarin74@ gmail.com. The direction of RNA polymerase-dependent DNA transcription is 5′ -> 3′ for both helix (+) and (-) strand transcription; Based on these four knowns, it can be postulated with a reason degree of certainty that the necessary prerequisite for gene transcription is a cellular pressuromodulation-dependent establishment of a horizontal 5′ -> 3′ reading frame of the most asymmetrically weighted 5′ -> 3′ anisotropic intergene segment pairs with respect to the gene (wrt gene) and the lesser asymmetrically weighted 5′ -> 3′ mesotropic intergene segment pairs (wrt gene), while the symmetrically weighted 3′ -> 5′ and 5′ -> 3′ isotropic intergene segment pairs (wrt gene) remain horizontal and function as stabilizing intergene segment pairs It can be postulated with a reason degree of certainty that the conserved basis for DNA transcription and replicative gene overexpression progression to mitogenic multi-nucleation is associated with decreased cell membrane compliance primarily related to increased endocytic cell membrane pressuromodulation, which results in mitogenic multi-nucleation, for example:. Gene symbol Number of Beginning (B), middle (M) and ending (E) of episodic episodes (number character as per 5′ -> 3′ prpTQs of final SEBs)
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