Abstract
Axon degeneration and regeneration are processes that are central to neural insults including spinal cord injury, brain trauma, ischemia, infection, inflammation, neurodegenerative diseases, and aging (Conforti et al., 2014). Injured axons undergo progressive self-destruction, termed “Wallerian degeneration”, which is named after August Volney Waller who was the first to describe degeneration of severed nerves in 1850 – the injured nerve fibers become fragmented like threaded beads and are gradually cleared away.
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