Abstract
Evaluation of: Webster TJ, Ejiofor JU: Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo. Biomaterials 25, 4731–4739 (2004) [1] . This article reviews a recent paper published in the field of nanotechnology as related to orthopedic implant formulations. Webster and Ejiofor have developed and characterized metals with nanoroughness and have evaluated their efficacy in an in vitro (cellular) setting. The bone-adhesive properties of these materials were found to surpass material formulations that are used currently in the design of orthopedic implants, including hip replacements. Follow-up experiments should focus on other bone and competitive cell lines, examination of subsequent cell functions, such as bone deposition, and testing in the complex in vivo environment of the human body. If successful, this foundation set of experiments will undoubtedly revolutionize the field of bone tissue engineering and replacement.
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