Abstract
Progressive multifocal leukoencephalopathy is a rare but important brain disease caused by JC virus. This polyomavirus typically causes an asymptomatic infection in healthy people. In a few individuals with chronic cellular immunodeficiency, JC virus evolves to become neurotropic, infecting and killing oligodendrocytes to cause a subacute progressive demyelinating disease that generally is fatal within 6 months from symptom onset. 1 Major EO Yousry TA Clifford DB Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned. Lancet Neurol. 2018; 17: 467-480 Summary Full Text Full Text PDF PubMed Scopus (104) Google Scholar BK virus-specific T cells for immunotherapy of progressive multifocal leukoencephalopathy: an open-label, single-cohort pilot studyWe showed that generation of polyomavirus-specific T cells from healthy related donors is feasible, and these cells can be safely used as an infusion for adoptive immunotherapy of progressive multifocal leukoencephalopathy. Although not powered to assess efficacy, our data provide additional support for this strategy as a potential life-saving therapy for some patients. Full-Text PDF
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