Abstract
Watson-Crick base pairing is believed to protect the Watson-Crick face of nucleobases in double-stranded DNA (dsDNA) from cytotoxic damage. Lesions on the Watson-Crick face are believed to occur when the DNA is transiently single stranded during replication and transcription. However, damage to the Watson-Crick face in dsDNA has been reported in vitro, but the mechanisms rendering dsDNA susceptible to damage remain poorly understood. in this work, we explored the role of Hoogsteen base pairs (bps) in mediating cytotoxic damage to dsDNA.
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