Abstract
Honokiol, a neolignan compound isolated from Magnolia species has been suggested to interact with GABAA receptors. Evidence comes from honokiol-induced enhanced [3H]muscimol binding [1] and anxiolytic action in behavioural studies [2]. The molecular mechanism and possible subunit-specific effects of honokiol on GABAA receptors are currently unknown.[...]
Highlights
A neolignan compound isolated from Magnolia species has been suggested to interact with GABAA receptors
In the present study we investigated the action of honokiol on GABAA receptors of 7 different subunit compositions (α1β2γ2s, α1β2, α1β1, α1β3, α2β2, α3β2 and α5β2) that were expressed in Xenopus oocytes
The strongest IGABA potentiation was observed for receptors containing α3 subunits (e.g. 2410% for α3β2)
Summary
A neolignan compound isolated from Magnolia species has been suggested to interact with GABAA receptors. Österreich 2 Institute of Pharmaceutical Biology, University of Basel, Klingelbergstraße 50, 4056, Basel, Switzerland 3 Department of Pharmacognosy, University of Graz, Universitätsplatz 4, 8010 Evidence comes from honokiolinduced enhanced [3H]muscimol binding [1] and anxiolytic action in behavioural studies [2].
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