Honeycomb structure is promising for the repair of human bone defects

Abstract

In this paper, the results of the study on the performance of four groups of different honeycomb structures show that the application of honeycomb structure in the design of biomimetic bone scaffold is feasible and promising. In terms of static properties, the elastic modulus (1.6–3 GPa) of the four scaffolds matched the elastic modulus of human cancellous bone (0.1–4.5 GPa), and the yield strength (88–146 MPa) was much higher than that of the femoral neck (0.56–3.71 MPa). In terms of permeability, except for the excessive permeability of SU scaffold, the permeability of the other three groups of scaffolds (1.5*10−8–4.8*10−8 m2) are all in the range of cancellous bone permeability (0.5*10−8–5.0*10−8 m2). In terms of the distribution of wall shear stress, the wall shear stress of the four groups of scaffolds ranged from 2.8 to 42.8 MPa, which could stimulate cells to deposit mineralized extracellular matrix (0.55–30 MPa) in the 3D scaffold, which was conducive to bone tissue regeneration.