Abstract
Background Tuberculosis (TB) remains an important cause of death among patients infected with HIV. Genetic variation influences differential development of TB particularly in Immunosupressed patients. Natural Killer cells play an important role in the innate immune system by providing the first line of defence against viral infections and tumors. Their activity is partially controlled by distinct inhibitory and activating killer Ig like receptors (KIR) that recognize specific ligands on potential target cells. Objective of this study is to determine the association between KIR and HIV co-infection.
Highlights
Tuberculosis (TB) remains an important cause of death among patients infected with HIV
Natural Killer cells play an important role in the innate immune system by providing the first line of defence against viral infections and tumors
Their activity is partially controlled by distinct inhibitory and activating killer Ig like receptors (KIR) that recognize specific ligands on potential target cells
Summary
Tuberculosis (TB) remains an important cause of death among patients infected with HIV. Genetic variation influences differential development of TB in Immunosupressed patients. Natural Killer cells play an important role in the innate immune system by providing the first line of defence against viral infections and tumors. Their activity is partially controlled by distinct inhibitory and activating killer Ig like receptors (KIR) that recognize specific ligands on potential target cells. Objective of this study is to determine the association between KIR and HIV co-infection
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