Abstract
Electrophysiological, biochemical and pharmacological data suggest that an impairment of inhibitory systems contribute to the generation of epileptiform activity of both interictal and ictal type within epileptic foci. Homotaurine, (3 aminopropanesulfonic acid, 3-APS) is a synthetic analog of GABA with powerful depressant action on central neurons. Systemic administration of 3-APS is capable of antagonizing the epileptogenic spiking activity of neocortical foci induced by Penicillin and conjugated estrogens in cats. Pretreatment with subcute 3-APS for 3 days also blocks the convulsant and cytotoxic effects of intraperitoneal injected Kainic Acid in rats. Systemically injected 3-APS potentiates a feline model of cortico-reticular epilepsy of Petit Mal type. Often compounds with suspected GABAmimetic properties, also activate or induce ex novo various models of bilaterally synchronous S-W discharges. Until data on the behavior of 3-APS in relation to the blood brain barrier becomes available the central action observed upon systemic administration of 3-APS can not be ascribed with certainty to 3-APS itself.
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