Abstract

In order to obtain comb-like poly-L-lysines bearing a biphenyl mesogen at the end of every repeating unit we have synthesised N e- 4-phenylbenzamido-L-lysine (Kφφ) and the corresponding N-carboxy anydride (Kφφ-NCA). We have homopolymerised the Kφφ-NCA and block-copolymerised it with the NCA of N e -trifluoroacetyl-L-lysine (Kt). The structural study of homopolymers pKt and pKφφ and block copolymers pKt/pKφφ was performed by infrared spectroscopy and X-ray diffraction. Two main types of structures were established: a bidimensional hexagonal one (Hα) where the polypeptide chains adopt an α-helix conformation and a lamellar smectic one (S A ) deriving from the β-pleated- sheet structure of polypeptides. Homopolymers pKt and block copolymers pKt/pKφφ rich in pKt exhibit the Hα structure, whereas the homopolymers pKφφ exhibit an S A2 structure, and block copolymers rich in pKφφ exhibit an S Ad structure. All the liquid-crystalline structures were stable until the beginning of decomposition of the polymers, Hydrolysis of the pKt block of copolymers pKt/pKφφ provided amphiphilic block copolymers pK/pKφφ without modification of the structure of the mesophases.

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