Abstract
ATP-Binding Cassette (ABC) transporters constitute one of the largest families of membrane proteins. These proteins transport a variety of substrates and are associated with a large number of diseases such as multi-drug resistance in cancer, diabetes, cystic fibrosis, and immune deficiencies. Several members of the ABC super-family act as a pump to import or export molecules; others are lipid flippases or regulatory subunits of potassium channels, and one member acts as a chloride channel. Despite this functional diversity, ABC transporters share a common mechanism of action, using energy derived from ATP hydrolysis to allow the translocation of their substrates.
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