Abstract
The cytochrome P450 sterol 14α-demethylase enzyme (CYP51) is the target of azole antifungals. Azoles block ergosterol synthesis, and thereby inhibit fungal growth, by binding in the active-site cavity of the enzyme and ligating the iron atom of the heme cofactor through a nitrogen atom of the azole.In this work, homology models of the CYP51 enzymes from Candida albicans were constructed based on the X-ray crystal structure of CYP51 from Saccharomyces cerevisiae .
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