Abstract
THE detection of Epstein-Barr virus (EBV) DNA in established lines of lymphocytes and in biopsies of Burkitt's lymphoma and nasopharyngeal carcinoma has been reported1–4. The average number of EBV genomes associated with virus nonproductive cells was estimated as forty to one hundred per cell by a nucleic acid hybridization technique with EBV-specific complementary RNA (cRNA) and cellular DNA3,4, whereas two to five genomes per cell were found by DNA–DNA hybridization on nitrocellulose filters1,2.
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