Homologous recombination DNA repair defects in copy-number high serous-like endometrial cancers

Abstract

Objective: Endometrial cancers (ECs) of copy-number high (serous-like) molecular subtype are characterized by high levels of copy-number alterations and recurrent TP53 mutations akin to high-grade serous ovarian (HGSOCs) and basal-like breast cancers, which are sensitive to platinum agents and/or PARP inhibitors. We aimed to assess whether copy-number high (serous-like) ECs show defects in homologous recombination DNA repair (HRD) akin to HGSOCs and basal-like breast cancers.